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Initially, GLP-1 was thought to correspond to proglucagon (72-108) suitable
with the N-terminal of the MPGF, but sequencing experiments of endogenous GLP-1 revealed a structure corresponding to
proglucagon (78-107) from which two discoveries were found.
Lixisenatide is based on the structure of
exendin-4 and has a half-life of 3 h. Recently, it has been observed that 4-week-treatment with exendin-4 reversed memory impairment in APP/PS1
mice, downregulating the aberrant N-acetylglucosaminyltransferase
III expression through the Akt/GSK-3β/β-catenin signaling pathway in neurons.
In the same PD rat model exendin-4 was able to promote adult
neurogenesis in vitro e in vivo, normalizing DA imbalance, showing an increase
in tyrosine hydroxylase- and vesicular monoamine transporter 2-positive neurons in the substantia nigra (Bertilsson et
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